Precision Mitochondria

ARIA has launched a programme backed by at least £55 million to make the mitochondrial genome programmable in vivo. The immediate goal is to achieve persistent, reproducible expression of a novel gene from engineered mitochondrial DNA (mtDNA) in a vertebrate system. The programme will fund the creation of a versatile toolkit to empower researchers with new capabilities. This toolkit will enable the delivery of nucleic acids into the mitochondrial matrix, the expression of functional proteins from the introduced genetic code, and the maintenance of engineered genomes through cellular replication.